First, let’s go over the basics. Type h to view a list of helpful shortcuts.
The following help window displays:

To close this window, click the X in the upper-right corner, or click the Close button in the lower-right corner. You can also click behind the window to close it. You can also access this list of shortcuts by clicking the Help menu and selecting Keyboard Shortcuts.
For additional help, select the Help sidebar to the right and click the Assist Me! button.
You can also type assist in a blank cell and press Ctrl+Enter. A list of common tasks displays to help you find the correct command.

There are multiple resources to help you get started with Flow in the Help sidebar. To access this document, select the Getting Started with H2O Flow link below the Help Topics heading.
You can also explore the pre-configured flows available in H2O Flow for a demonstration of how to create a flow. To view the example flows, click the Browse installed packs… link in the Packs subsection of the Help sidebar. Click the examples folder and select the example flow from the list.

If you have a flow currently open, a confirmation window appears asking if the current notebook should be replaced. To load the example flow, click the Load Notebook button.
To view the REST API documentation, click the Help tab in the sidebar and then select the type of REST API documentation (Routes or Schemas).

Before getting started with H2O Flow, make sure you understand the different cell modes.