Item # Length Source of Standard Year Implemented Version Implemented Year Retired Version Retired
3956 1 SEER 2022 22

NAACCR XML: Tumor.p16

Description
The p16 biomarker is over-expressed (produced) in response to HPV. It is therefore a surrogate marker for HPV disease.
Rationale
Patients with HPV have a different survival or outcome so it is important to be able to distinguish this by documenting the p16 results. Testing is performed by immunohistochemistry (IHC) which is inexpensive and has near universal availability. It has an easily standardized interpretation. HPV testing is usually performed through DNA testing which is more expensive and less widely available. HPV testing also has technically more variability with the interpretation.
p16 is a tumor suppressor protein also known as cyclin-dependent kinase inhibitor 2A. The p16 biomarker is over-expressed (produced) in response to HPV. It is therefore a surrogate marker for HPV disease.
Codes
0p16 Negative; Nonreactive
1p16 Positive; Diffuse, Strong reactivity
8Not applicable: Information not collected for this case
(If this time is required by your standard setter, use of code 8 will result in an edit error).
9Not tested for p16; Unknown
BlankDiagnosis year prior to 2021
Note: See the SSDI Manual for coding instructions.
Anus schema added/ Please note for CCCR p16 for Cervix changed from "." to RS* retroactive to 2021