Profound Immune Suppression, suppressed immune status that may be associated with HIV/AIDs, solid organ transplant, chronic lymphocytic leukemia, non-Hodgkin lymphoma, multiple conditions or other conditions, increases the risk of developing Merkel Cell Carcinoma and is an adverse prognostic factor.

Profound Immune Suppression is a Registry Data Collection Variable in AJCC. It was previously collected as Merkel Cell Penis, SSF #22, Merkel Cell Scrotum SSF #22, Merkel Cell Skin, SSF# 22, and Merkel Cell Vulva, SSF# 22.

Item #	Length	Source of Standard	Year Implemented	Version Implemented	Year Retired	Version Retired
3918	1	NAACCR	2018	18

0	No immune suppression condition(s) identified/not present
1	Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS)
2	Solid organ transplant recipient
3	Chronic lymphocytic leukemia
4	Non-Hodgkin lymphoma
5	Multiple immune suppression conditions
6	Profound immune suppression present
8	Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.)
9	Not documented in medical record Profound immune suppression not assessed or unknown if assessed

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.