S Category Pathological combines the results of post-orchiectomy Alpha Fetoprotein (AFP), Human Chorionic Gonadotropin (hCG) and Lactate Dehydrogenase (LDH) into a summary S value.

Item #	Length	Source of Standard	Year Implemented	Version Implemented	Year Retired	Version Retired
3924	1	NAACCR	2018	18

S Category Pathological is required for prognostic stage grouping in AJCC 8th edition, Chapter 59, Testis. It is a new data item for cases diagnosed 1/1/2018+.

0	S0: Marker study levels within normal levels
1	S1: At least one of these values is elevated AND LDH less than 1.5 x N* AND hCG (mIU/L) less than 5,000 AND AFP (ng/mL) less than 1,000
2	S2 LDH 1.5 x N* to 10 x N* OR hCG (mIU/L) 5,000 to 50,000 OR AFP (ng/mL) 1,000 to 10,000
3	S3: Only one elevated test is needed LDH greater than 10 x N* OR hcG (mIU/mL) greater than 50,000 OR AFP (ng/mL) greater than 10,000
5	Post orchiectomy serum tumor markers unknown or not done but pre orchiectomy serum tumor markers were normal
9	SX: Not documented in medical record S Category Pathological not assessed or unknown if assessed

*N indicates the upper limit of normal for the LDH assay.

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.